Paul Fairchild

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Profile

University Lecturer in the Immunobiology of Stem Cells, Oxford Martin Senior Fellow, and Research Councils UK Academic Fellow within the Sir William Dunn School of Pathology. He was the Founder and Co-Director of the Oxford Stem Cell Institute from 2008-2015. Professor Fairchild obtained his DPhil at the University of Oxford for his research on the immune response to organ allografts. He currently works within the emerging field of cell replacement theory and regenerative medicine to investigate the immune response to tissues differentiated from embryonic stem cells. His work on induced pluripotent stem cells (iPSC) aims to promote the indefinite survival of stem cell-derived grafts.

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Interviewer

Dr. Kezia Gaitskell, Pathology Registrar and doctoral researcher in Nuffield Department of Population Health, University of Oxford

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Links

Oxford Stem Cell Institute

Sir William Dunn School of Pathology

Oxford Martin School

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Select Publications

Silk KM, Silk JD, Ichiryu N, Davies TJ, Carpenter L, Watt SM, Cerundolo V, Fairchild PJ

2012 Cross-presentation of tumor antigens by induced pluripotent stem cell-derived CD141+XCR1+ dendritic cells. Gene Therapy 19: 1035-1040.

Lui KO, Boyd AS, Cobbold SP, Waldmann H and Fairchild PJ

2010 A role for regulatory T cells in acceptance of embryonic stem cell-derived tissues transplanted across an MHC barrier. Stem Cells 28: 1905-1914.

Fairchild PJ 2010 The challenge of immunogenicity in the quest for induced pluripotency. Nature Rev Immunol. 10: 868-875.

Robertson NJ, Brook F, Gardner RL, Cobbold SP, Waldmann H and Fairchild PJ

2007 Embryonic stem cell-derived tissues are immunogenic but their innate immune privilege promotes the induction of tolerance. Proc Natl Acad Sci USA 104: 20920-20925.

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